Can buddypress on multisite be configured to work using mapped domains

Networked activated buddypress with domain mapping set to map to original domain works fine. However, I want to use domain mapping set to the mapped domain, which Buddypress then stops working.

Is this possible without using networks + with seperate Buddypress installs configured?

Read about enabling BP multiblog in my wp-config, but did not think this was a solution?