Considering allowing comments (spam management question)

So, I’m considering allowing comments for one of my information sites. This is a site I don’t have time to manage constantly and right now, is pretty much set-it-and-forget-it. I’d like to open it up for user comments, but I’m concerned about managing spam.

What plug-ins should I use (I’m avoiding akismet, because I hear it can throttle service) and are there any plug-ins that can work pretty much effectively without my constant attention and management?